Both teams know a win will likely see them safe for another season in the top flight, while defeat leaves everything hanging on the final week.
David Moyes saw his team hammer Norwich in the last match, but Nigel Pearson’s men have back-to-back wins themselves.
It will be a test of nerves as well as in who can find the attacking quality to come out with an all-important victory.
Here’s everything you need to know about the game.
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When is it and what time is kick-off?
The match will begin at 8pm on Friday 17 July at London Stadium.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Premier League, Sky Sports Main Event and Sky Sports Ultra HD, and Sky subscribers can also stream the game on the Sky Go app.
If you’re not a Sky customer, you can grab a NOWTV Day Pass here to watch without a subscription.
What is the team news?
West Ham are missing attacking midfield duo Felipe Anderson and Robert Snodgrass, but are otherwise looking at a clean bill of health.
Watford are similarly not affected by any new injuries. Gerard Deulofeu, Daryl Janmaat and Isaac Success are all longer-term absentees from the team sheet.
West Ham: Fabianski; Fredericks, Diop, Ogbonna, Cresswell; Noble, Rice, Soucek; Bowen, Yarmolenko, Antonio.
Watford: Foster; Femenia, Dawson, Kabasele, Masina; Hughes, Capoue; Sarr, Doucoure, Welbeck; Deeney.
What are the odds?
West Ham: 10/7