Vitamin B12 deficiency symptoms: The unusual sign on your skin to watch out for

Vitamin B12 is tasked with many important roles, such as keeping the body’s nerve and blood cells healthy and helps make DNA, the genetic material in all cells. It is easy to take for granted the role B12 plays in the body if you haven’t become deficient in it. If you are unfortunate enough to fall into this camp, you will have a newfound appreciation for B12.

Without it, the instructions for building the cells are incomplete, and cells are unable to divide, research shows.

This causes a type of anaemia called megaloblastic anaemia, whereby red blood cells produced in your bone marrow are large and fragile.

These red blood cells are too large to pass out of your bone marrow and into your circulation. Therefore, you don’t have as many red blood cells circulating around your body, and your skin can appear pale in colour.

The fragility of these cells also means that many of them break down, causing an excess of bilirubin.

Bilirubin is a slightly red or brown-coloured substance, which is produced by the liver when it breaks down old blood cells.

According to a clinical study of jaundice, large amounts of bilirubin are what give your skin and eyes a yellow tinge.

What should I do if I recognise the warning signs of B12 deficiency?

See a GP if you’re experiencing symptoms of vitamin B12 or folate deficiency anaemia.

As the NHS explains, these conditions can often be diagnosed based on your symptoms and the results of a blood test.

How to treat it

Vitamin B12 deficiency anaemia is usually treated with injections of vitamin B12.

There are two types of vitamin B12 injections:

  • Hydroxocobalamin
  • Cyanocobalamin

“If your vitamin B12 deficiency is caused by a lack of the vitamin in your diet, you may be prescribed vitamin B12 tablets to take every day between meals,” explains the NHS.

B12 is naturally found in the following foods:

  • Meat
  • Salmon and cod
  • Milk and other dairy products
  • Eggs


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