The singer-songwriter, one of the most influential figures in US folk and country music, had been in a critical condition after contracting Covid-19.
Two-time Grammy winner Prine had been in hospital since last month and his wife and manager, Fiona, said on March 17 that she had tested positive for coronavirus after they returned from a European tour.
Country music singer Margo Price was among those to pay tribute to Prine, who Rolling Stone called “one of America’s greatest songwriters”.
She tweeted: “It hurts so bad to read the news. I am gutted. My hero is gone. My friend is gone. We’ll love you forever John Prine.”
Oscar-winning filmmaker Taika Waititi said: “RIP John Prine. This sucks.”
Actress Rosanna Arquette shared a playlist of Prine’s music and wrote: “God bless you John Prine rest in power.”