Health

Dominant coronavirus strain has mutated to be 10 times more infectious, scientists warn


A DOMINANT strain of the coronavirus has mutated to be ten times more infectious, experts have claimed.

Researchers found the strain is more infectious than others as it doesn’t break off once it enters the body.

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Scientists have said one strain of the coronavirus has got ten times stronger

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Scientists have said one strain of the coronavirus has got ten times strongerCredit: PA:Press Association

A team at The Scripps Research Institute in Florida examined a spike protein.

The lead researcher on the paper Dr Hyeryun Choe said the mutation of the virus strain had happened in order to “compensate for the past spike proteins”.

A spike protein is what the virus uses to attach to cells in the airways – the ACE-2 receptor.

ACE-2 receptors are entry points which viruses use to get into the body.

Microscope image of a SARS-CoV-2 spike protein side view, the green part reduces shedding

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Microscope image of a SARS-CoV-2 spike protein side view, the green part reduces sheddingCredit: Scripps.Edu

The researchers claim that this has adapted since January.

During the first few months of the pandemic it would break off but Dr Choe said it is now more resilient.

Their research has not yet been peer reviewed and was published on bioRxiv.

So far in the UK over 43,000 people have died from the virus.

 

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Leicester has become the first city to be put under localised lockdown due to a rise in cases and the new study suggests that the current strain of the virus is even more infectious than before.

The scientists say it is now ten times more infectious than it was when it was first found in humans in China.

Writing in the study Dr Choe said: “Viruses with this mutation were much more infectious than those without the mutation in the cell culture system we used.”

‘Not accidental’

The co-author of the paper Dr Michael Farzan added: “Over time, it has figured out how to hold on better and not fall apart until it needs to.”

The mutated version is called SG614 formally D614.

It is the dominant strain in Covid patients in Canada, Italy the UK and the US.

Speaking to the Washington Post Dr Choe said: “The epidemiological study and our data together really explain why the [G variant’s] spread in Europe and the US was really fast… This is not just accidental.”

Despite the strength of the spike, researchers said that it was not giving people more severe symptoms.

12 strains of the killer bug were found in the UK in March

Dr Choe’s study added: “An interesting question is why viruses carrying the more stable SG614 appear to be more transmissible without resulting in a major observable difference in disease severity.

“It is possible that higher levels of functional S protein observed with SG614 increase the chance of host-to-host transmission, but that other factors limit the rate and efficiency of intra-host replication.”

The SG614 strain of the virus was first found in Germany in February.
It forces out older strains of the virus when they clash inside of the body.

The researchers added: “Through March, G614 became increasingly common throughout Europe, and by April it dominated contemporary sampling. 

“In North America, infections were initiated and established across the continent by the original D614 form, but in early March, the G614 was introduced into both Canada and the USA, and by the end of March it had become the dominant form in both nations.”

Last month it was reported that there were over 12 strains of the virus in the UK recorded in March.

Scientists analysed the genomes of the deadly virus in 260 infected patients across the country.

They discovered at least 12 strains of coronavirus, one of which has only ever been found in the UK – meaning it mutated on British soil.

The scientists concluded most of the strains came from Italy and Spain, the worst-hit countries in the world at the time the research was carried out.

It found strains had also come from China, the US and Australia.

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