It had been five years and seven months since his last cap when he scored twice against Armenia in 2015 – only one player has had to wait longer between caps when Roger Scotti went five years and 11 months after returning in October 1956.
However, it was not a happy night for the 33-year-old, who found himself claiming an unwanted record from the penalty spot.
France took on Wales in a warm-up match ahead of Euro 2020 this summer, which was postponed last year.
After Liverpool ace Neco Williams was sent off, Les Bleus would go on to win 3-0 in a routine victory.
But while the defender might feel aggrieved to have received a red card, Benzema failed to capitalise when his resulting penalty was saved.
It means the striker has now missed his last three spot-kicks for France, with the other two coming against Switzerland in the 2014 World Cup and a friendly vs Sweden.
Benzema is now up to 82 caps for his country, a hefty amount considering his five-year hiatus.
Considering Benzema has been a consistently brilliant player for Real Madrid during that time, why has Deschamps avoided calling the forward up to his squad?
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Due to his alleged involvement in an attempt to blackmail his former France teammate Matthieu Valbuena in a “sex tape” scandal, the Bernabeu frontman was left out of the squad by Deschamps.
A trial is due to take place after this summer’s tournament, on 20-22 October.
Benzema vehemently denies all charges and condemned Deschamps for having “bowed to the pressure of a racist part of France”.
Not long after, the France manager’s holiday home was vandalised with the word “racist” sprawled on it.
In 2020, Deschamps opened up over the fiasco, saying: “There have been very unpleasant moments which were outside of the context of football, when it went on the private and personal sphere.
“Am I thinking about the tag? Yes. I will never be able to forget it. Then, it went too far. It was violent, inappropriate and unacceptable.”