England and Scotland will have a strong contingent in the Europa League last 16.
Manchester United, Arsenal and Wolves are primed to advance, while Celtic should join rivals Rangers in the next round too.
The strongest contenders will also likely include Sporting CP, Eintracht Frankfurt and Basel, while Inter Milan are the outright favourites, led by Romelu Lukaku.
With domestic matters providing all three of the English teams with a real battle to secure European places for next season again, each may see winning the Europa League as their best route to both success and the Champions League for 2019/20.
Here is all the information you need to follow the draw for the next knock-out round.
When and where is the Europa League draw?
The draw will take place on Friday, February 28, beginning at 12 noon (GMT).
It will be held at UEFA headquarters in Nyon, Switzerland.
How can I watch the draw?
The draw will be broadcast on UK TV by BT Sport 1, starting at 12 noon.
It can be streamed online via the UEFA website from this link, also starting at midday, while we will also be providing a dedicated live blog for the entirety of the draw here on the Independent.
Key dates
Pending the draw and any enforced changes, the round of 16 ties are scheduled to take place on Thursday, March 12 (first leg) and Thursday, March 19 (second leg). UEFA will confirm kick-off dates and times shortly after the draw.
Europa League teams
There are no seeded teams and no country protection at this stage – it is an entirely open draw. The following teams are in the draw:
Arsenal/Olympiacos
Basel/APOEL
Bayer Leverkusen/Porto
Celtic/Copenhagen
Eintracht Frankfurt/Salzburg
Getafe/Ajax
Inter Milan/Ludogorets
LASK/AZ Alkmaar
Manchester United/Club Brugge
Rangers
Roma/Gent
Sporting CP/Istanbul Basaksehir
Sevilla/Cluj CFR
Shakhtar Donetsk/Benfica
Wolfsburg/Malmo
Odds
Inter Milan 5/1
Man United 6/1
Sevilla 8/1
Arsenal 8/1
Wolves 15/2