Ole Gunnar Solskjaer’s side are just three points adrift of fourth-placed Chelsea and have received a huge boost in the returns of Marcus Rashford and Paul Pogba from injury.
For Jose Mourinho, coming up against his former side, there is no space to slip-up. Spurs are currently languishing in eighth, seven points adrift of the top four, and could even face a tense fight to secure a Europa League spot.
However, Tottenham too will have silver linings to take from the enforced break, with captain Harry Kane returning to the fore.
Here is everything you need to know:
When is it and what time is kick-off?
The match will take place at the Tottenham Hotspur Stadium on Friday 19 June. Kick-off is at 8.15pm.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League following the conclusion of Norwich vs. Southampton.
What is the team news?
Dele Alli has been ruled out of the fixture after being handed a one-game ban by the FA. Harry Kane, Moussa Sissoko and Steven Berwijn have all benefited from the layoff, with Jose Mourinho stating that the trio have all now fully recovered from long injury absences.
Meanwhile, United will also receive a major boost in the returns of Marcus Rashford and Paul Pogba.
What are the predicted line-ups?
Tottenham: Lloris, Aurier, Alderweireld, Dier, Davies, Winks, Lo Celso, Sissoko, Bergwijn, Lucas, Kane.
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Matic, Williams, Fernandes, James, Martial
Jose Mourinho will be desperate, as always, to get the best of his former club. However, I expect United to continue the momentum they gained prior to the break and dominate the midfield, with McTominay, Fred, Fernandes and Pogba all available, and edge a close-fought encounter.
Tottenham 1-2 Manchester United
What are the odds?
Tottenham – 17/10
Draw – 12/5
Manchester United – 6/4