Lucas Torreira appears set to return to Italy with a number of Serie A sides expressing interest and Mohamed Elneny will also be allowed to leave after returning from a season-long loan with Besiktas.
Arsenal will also look to move the likes of Sokratis Papastathopoulos, Shkodran Mustafi, Sead Kolasinac, Calum Chambers and Mesut Ozil.
Kolasinac has been linked with a move to Schalke whereas Holding is closing in on a loan deal with Newcastle.
Leeds are keeping tabs on Chambers and are also said to be interested in Emiliano Martinez following his impressive performances between the sticks as he replaced the injured Bernd Leno.