Taking a commonly prescribed class of antibiotics may DOUBLE your chances of getting a ‘leaky valve’ which leads to heart failure, study claims
- Fluoroquinolone antibiotics commonly used to treat chest infections and UTIs
- GPs prescribe over 600,000 each year and like fact they tackle range of bacteria
- US researchers have found they double chance of potentially deadly leaky valve
Taking a common class of antibiotics may more than double your chances of getting a serious heart condition, a study suggests.
Researchers found patients using fluoroquinolones had a greater risk of developing aortic and mitral regurgitation, which can lead to heart failure.
The drugs are commonly used to treat everything from chest infections to urinary tract bugs.
Taking fluoroquinolone antibiotics more than doubles your chance of a potentially deadly heart condition, a study suggests. Ciprofloxacin (pictured) is the most prescribed of these
Ciprofloxacin is the most prescribed of these, but other types include levofloxacin, moxifloxacin and norfloxacin.
Researchers at the University of British Columbia (UBC) looked at 125,020 patients who’d taken antibiotics in the last year.
Some had been prescribed fluoroquinolones while others had taken amoxicillin or azithromycin – other types of antibiotics.
The research team discovered 12,505 cases of a leaky valve, which can affect how blood flows around the body.
They found current fluoroquinolone users were 2.4 times more likely to develop the condition than those on amoxicillin.
Meanwhile, patients on fluoroquinolone were at a 1.8 times greater risk than those using azithromycin.
Those who had come off fluoroquinolone within the last 60 days were 1.5 times more likely to develop a leaky valve compared with amoxicillin users.
Lead author Dr Mahyar Etminan suggested that fluoroquinolones were being over-prescribed due to convenience.
The associate professor of ophthalmology and visual sciences at UBC said: ‘You can send patients home with a once-a-day pill.
‘This class of antibiotics is very convenient, but for the majority of cases, especially community-related infections, they’re not really needed.
‘The inappropriate prescribing may cause both antibiotic resistance as well as serious heart problems.’
The researchers hope their study helps inform the public and physicians that if patients present with cardiac issues, where no other cause has been discovered, fluoroquinolone antibiotics could potentially be a cause.
The findings were published in the Journal of the American College of Cardiology.
Figures suggest more than 675,000 fluoroquinolones were dispensed by GPs and other practitioners in England alone, and about the same amount again in hospitals.
But there have been claims the drugs – considered to be safe – can have side effects, such as tendon rupture, joint problems and nerve pain.
It’s thought that because fluoroquinolones act on the mitochondria – powerhouses in cells responsible for releasing energy – effects can be felt all over the body, sometimes permanently.
Between 1990 to 2018, there were nearly 11,000 adverse reactions and 107 deaths reported in the UK for ciprofloxacin.