In a candid interview, Susanna was asked if she worried her television sidekick would leave.
She told OK! Magazine: “I think we work extremely well together and we have a partnership that has become quite important to people, so I think if Piers leaves that would be a terrible shame.”
The former BBC Breakfast host went on to joke that she would move on with another television husband if he did decide to quit.
“Don’t forget, I have been doing TV with lots of different TV husbands over the years, so he would just be another one,” she added to the publication.
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Piers then joked that he wouldn’t hear from her if he left, prompting her to reply: “That is not true!”
The former newspaper editor has previously explained his reasons why he thought about stepping down from his role on the show.
The father-of-four admitted he found the early 4am starts challenging ahead of the show’s start time.
After speaking with producers, Piers revealed his wake-up call changed to a later time.
The television duo spoke out about their close friendship in an interview last year.
Piers joked that the pair would be “at it like stoats in a sack” if they were both single.
Susanna added: “With other people, of course.”
Piers has been married to Celia Walden since 2010 and the pair share eight-year-old daughter Elise.
He also has three sons with his ex-wife Marion Shalloe.
Susanna is currently single following her split from Crystal Palace boss Steve Parish last year.
The presenter has three children with her ex long-term partner Dominic Cotton.
Good Morning Britain continues tomorrow at 6am on ITV.
Read the full interview in OK! Magazine out now.