Another seven games follow on Saturday, with reigning champions Manchester City hosting Brighton and Chelsea taking on Sheffield United.
Elsewhere, Watford – who prop up the league having yet to pick up a point – visit a revitalised Newcastle, after the Magpies beat Tottenham in the capital a week ago.
Leicester City take on Bournemouth in an intriguing showdown in the Midlands while Crystal Palace play host to Aston Villa and Norwich City visit West Ham United.
The day’s evening kick-off sees Burnley host top-of-the-table Liverpool, the only team with a 100 per cent record after three matches.
In Sunday’s two-game billing, Everton host Wolves – fresh from booking their spot in the Europa League group stages on Thursday night – before the north London derby rounds off the weekend.
Just one point split the two teams last term, Spurs pipping their bitter rivals to fourth spot as a result.
And Unai Emery’s side will hope to build on the encouragement of their performance at Anfield by claiming a home derby win, having not lost to Spurs in the league at the Emirates since November 2010.
BT Sport put their reputation on the line by trying to call every single fixture in the 2019/20 campaign – before a ball was even kicked.
‘The Script’ was generated using the help of football data and analysis experts Opta, Google and Squawka, picking the result of every match as well as the result of key end-of-season awards such as the Golden Boot and Golden Glove.
Their supercomputer has crunched the numbers to conjure up the expected outcomes for this weekend’s clashes – but who do they think will win between Arsenal and Spurs? And which team will sit at the summit?
BT Sport’s ‘The Script’ Premier League predictions
Southampton 0-0 Manchester United
Newcastle United 3-1 Watford
Chelsea 1-0 Sheffield United
Crystal Palace 2-1 Aston Villa
Leicester City 2-2 Bournemouth
Manchester City 2-1 Brighton & Hove Albion
West Ham United 3-1 Norwich City
Burnley 0-3 Liverpool
Everton 1-1 Wolves
Arsenal 2-2 Tottenham Hotspur
What BT Sport’s ‘The Script’ results would mean for the Premier League
Those results would see Liverpool maintain their perfect record and sit two points ahead of title rivals City.
Arsenal would be five points off the summit, with Spurs and United both six adrift, while Chelsea would jump level on points with the Gunners.
Watford’s wait for a first point of the season would continue, while Newcastle would lift themselves out of the relegation zone, which Norwich would slip into joining Watford and Aston Villa.
Wolves would join Watford as the only other team yet to claim a victory, having drawn their three matches going into the fourth match-day.