Hazard is still recovering from a hairline fracture in his foot which he suffered against Paris Saint-Germain in the Champions League in November.
Instead, Isco is likely to start on the left-hand-side of a three-pronged attack playing behind Karim Benezema.
Real Madrid predicted 4-2-3-1 line-up vs Osasuna.
Courtois, Carvajal, Ramos, Varane, Mendy; Kroos, Casimero; Bale, Modric, Isco; Benzema
