Miraculous 'bio-glue' can heal fatal wounds to organs in seconds is developed by scientists

A ‘miracle’ glue that can close up fatal wounds within seconds could be used to save lives where medical help isn’t immediately available.

Tested on pig models, the gel like substance forms a seal around tissue openings in just 20 seconds after being activated with UV light.

The glue could be used to stop patients bleeding to death during heart surgery, or in emergencies with limited medical access such as war zones and terrorist attacks.

A ‘miracle’ glue that can close up fatal wounds within seconds could be used to save lives where medical help isn’t immediately available

In a video demonstrating its usage, the ‘bio-glue’ is shown first being ‘activated’ by UV (ultraviolet) light shone at an opening on a pig liver using a hand held torch.

The gel is made up of water, gelatin and a mix of chemicals that is injected into the injured tissue.

After being activated, it sets quickly, forming a waterproof seal and stops blood-like liquid leaking through.

According to its inventors, the glue is effective even on wet tissue, therefore eliminating the need for staples or stitches to close wounds.

The innovation has been made by scientists at the Zhejiang University of Medicine in China who say the application of the material could range from surgery to the battlefield or civilian catastrophes, either accidental or deliberate.

Professor Hongwei Ouyang, the author of the paper who specialises in regenerative therapy at the university said: ‘Uncontrollable bleeding is a major problem in surgical procedures and after major trauma.

‘Existing clotting substances poorly control haemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues.’

Until now, medical glue has not proved strong enough to withstand the forces inside the pumping chambers of the heart or major blood vessels.

Professor Ouyang added: ‘The triggered hydrogel is like rubber. We can even say it is like a connective tissue.

‘Upon UV irradiation, organic compounds at the tissue-hydrogel interface react with amino groups of the tissue proteins, forming strong bonds.’

‘The components and mechanical properties of the hydrogel mimic those of human soft tissues.’

Tested on pig models, the gel like substance forms a seal around tissue openings in just 20 seconds after being activated with UV light. The image shows the initial bleeding wound on a pig liver at the beginning of the experiment

The ‘bio-glue’ is applied and the activated by UV (ultraviolet) light shone at the opening cauing the bleeding on a pig liver with a hand held torch. This is shown in the image above

The authors of the study say the glue could be used to stop patients bleeding to death during heart surgery, or in emergencies with limited medical access such as war zones and terrorist attacks. The image shows the pig liver after the hydrogel created a seal around the bleeding

In the current study, experiments were performed on pigs who were chosen because their organs are a similar size to human’ Professor Ouyang added.

The gel was able to close up incisions and holes 6mm wide in the blood vessels as well as organs in just 20 seconds, according to the report.

The seals are also waterproof and eliminates the need for stitching or stapling.

‘With a UV ﬂashlight or an optical ﬁbre, this material can potentially be used for completely stitchless sealing, which make it a promising bio-glue for use in surgery and emergency clotting,’ said Professor Ouyang.

Surgical procedures using the hydrogel repaired the pigs’ hearts without the need for stitches in further experiments.

Three of the pigs involved were monitored for a two-week period and they made full recoveries with no abnormalities or side effects.

Professor Ouyang hopes the technology will be available for human use in three years.

‘This glue could be used in a human surgical setting in three to five years. Current commercial medical glue cannot handle heart bleeding.

‘These help to mimic the support structure of cells called the ‘extracellular matrix’, a complex composition of proteins and other molecules.

Gel-based solutions require both strong adhesion to the wet tissue and the strength to resist high blood pressure and the movement of a beating heart.

But very few non-toxic materials meet these criteria, said Profesor Ouyang.

Further studies are now being planned to confirm the safety of the glue in further tests – including those involving humans.

The full study is published in Nature Communications.

HOW DOES ‘BIOGLUE’ WORK?

The glue could replace traditional sealing techniques used in medical such as surgery.

It is a gel made up of water, gelatin and a mix of chemicals that is injected into the injured and bleeding tissue.

The can undergo rapid gelling and sticks quickly to bleeding arteries and cardiac walls after being activated with UV light.

The process of gel setting forms a waterproof sealant that stops the bleeding.

Makers of the gel from Zhejiang University in China say it can withstand high pressures in the heart and arteries and can be used alone without the need for stitching or stapling of the tissue.

Experiments using the gel has so far been carried out on pig livers and pigs which recovered fully after two weeks, say the authors of the study.

The hydrogel stopped high pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes.

Scientists say the technology could be ready to use on humans within three years.

It could be used to stop patients bleeding to death during heart surgery, or in emergencies with limited medical access such as war zones and terrorist attacks.

READ SOURCE