Men have a higher risk of cancer because of ‘intrinsic biological differences’ NOT because they eat, drink and smoke more, major study claims
- Both high alcohol and tobacco consumption linked to a swathe of cancers
- Experts thought men’s drinking and smoking habits behind higher cancer rates
- But major study suggests biology makes men more vulnerable to the disease
Men drink and smoke more than women — but that is not the reason they have a higher cancer risk.
A major study suggests biological differences are the real reason behind the disparity between sexes.
Understanding these differences could help to improve prevention and treatment, researchers say.
The study looked at 300,000 middle-aged and older Americans who did not have cancer over 15 years.
Men were more than twice as likely to develop the disease compared to women — even when lifestyle factors were ruled out.
‘This suggests that there are intrinsic biological differences between men and women that affect susceptibility to cancer,’ said lead researcher Dr Sarah Jackson, an epidemiologist at the National Cancer Institute.
Researchers suggested differences in genes, hormones and the immune system all play a role.
Scientists have thought men’s propensity to enjoy a few more drinks and take more smoke breaks than women was why they had higher rates of cancer in general. But now a major study of 300,000 Americans by the National Cancer Institute suggests biology makes men more vulnerable to cancer, not bad health habits
Some 182,000 women are diagnosed with cancer in the UK every year, rising to 193,000 among men.
In the US, 970,000 men and 928,000 women have cancer confirmed annually.
Researchers from the NCI examined the rates of 21 types of cancers in 171,274 men and 122,826 women.
Participants were aged 50 to 71 and their records were monitored between 1995 and 2011.
The findings, published in the journal CANCER, show 17,951 cancers were detected among men, while just 8,742 were diagnosed among women.
Rates of thyroid and gallbladder cancer were higher among women, but the prevalence of all other cancers were higher among men.
They did not look at cancers that are sex-specific – like womb cancer or prostate cancer.
Men were 11-times more likely to develop oesophageal cancer and four times more at risk of stomach or throat cancer.
They also had a three times greater chance of being diagnosed with bladder cancer.
Further analysis found men were still more likely to develop cancer overall when other risk factors like smoking, alcohol intake and exposure to carcinogens were accounted for.
Scientists have previously pointed to higher rates of smoking, alcohol consumption and exposure to chemicals like asbestos in factories.
They also said men may be less likely to seek medical advice.
The team suggested the male sex hormone testosterone may increase the likelihood of skin, prostate and liver cancer among men by promoting cell growth.
Meanwhile, they said women appear to mount a stronger immune response against oncogenic infections — those which can cause cancer, such as hepatitis and HPV — which could lower their risk of some cancers in comparison to men.
And research suggests women have an extra copy of genes that protect against cancer compared to men, which could offer them further protection.
Study leader Dr Sarah Jackson, an epidemiologist at the National Cancer Institute, said: ‘Our results show that there are differences in cancer incidence that are not explained by environmental exposures alone.’