New Manchester United star Harry Maguire is in line to make his debut after signing from Leicester for a world-record fee for a defender.
Midfielder Paul Pogba is also in contention following a back injury, but Alexis Sanchez is unlikely to feature following his involvement in the Copa America this summer.
Chelsea could be without N’Golo Kante, who is a doubt with the knee injury that disrupted his pre-season.
Ruben Loftus-Cheek, Antonio Rudiger and Callum Hudson-Odoi all remain sidelined for the Blues.
What have the managers said?
Manchester United boss Ole Gunnar Solskjaer: “I’m very confident that we’ll get goals from (Anthony) Martial, Daniel James, (Marcus) Rashford and Jesse Lingard.
“I believe Mason Greenwood is going to be playing and involved a lot and, when he is, he’s going to score goals.”
Chelsea manager Frank Lampard: “We have to remain competitive while we are in this position.
“With the ban it has been easy to write off this squad, and I don’t write off this squad at all.
“I think that what is important is that you have a target within the group. What matters is how we approach things. We will see how we go.”
What time does Man Utd vs Chelsea kick-off?
The Premier League clash kicks off at 4.30pm.
What TV channel is Man Utd vs Chelsea on?
Live television coverage can be found on Sky Sports Main Event.
You can also watch the game on NOW TV – for more information on how to subscribe, click here.
Build-up coverage gets underway following the conclusion of Newcastle vs Arsenal.
Can I live stream Man Utd vs Chelsea?
Streaming is available through the Sky Go app for existing customers.
This can be done through a range of mobile devices, tablets, computers and games consoles.
