Manchester United’s tally of 13 points after 11 league games is their lowest since 1986.
The Red Devils also suffered their fourth defeat of the season against Bournemouth last time out.
Brighton, meanwhile, have made a fine start to the campaign.
They’ve won four and drawn three of their opening 11 games in the Premier League under Graham Potter.
The Seagulls are also looking to equal their top-flight record of three straight wins, set in October 2018.
Man Utd vs Brighton team news
Scott McTominay is a doubt for United after suffering a knock to his foot in the midweek Europa League win.
Harry Maguire will undergo a late assessment but Victor Lindelof could return from a back injury.
Ashley Young is suspended after picking up his fifth booking of the season against the Cherries last weekend.
As for Brighton, defender Adam Webster is sidelined with an ankle problem.
Leandro Trossard is in contention to start after scoring as a substitute against Norwich.
Manchester United predicted XI: De Gea; Wan-Bissaka, Maguire, Rojo, Williams; McTominay, Fred; James, Pereira, Rashford; Martial
Brighton predicted XI: Ryan; Montoya, Duffy, Dunk, Burn; Trossard, Stephens, Propper, Alzate; Connolly, Maupay
Man Utd vs Brighton match prediction
Old Trafford is a fortress when it comes to playing Brighton.
United have not lost in their 11 previous home meetings with the Seagulls, winning nine times and drawing twice.
The last three meetings have all been settled by a one-goal margin, indicating it could be a close game.
Predicted scoreline: Manchester United 2-1 Brighton