Kevin Zegers – 2003
The Golden Globe nominee dated Kevin Zegers, best known for as Damien Dalgaard in Gossip Girl, during the summer of 2003.
The exes were both in their early careers as they navigated their short-lived teenage romance.
First love: Her first public boyfriend was Kevin Zegers, 33, the star of Air Bud, who she dated in 2003 at just 18-years-old
Thad Luckinbill (2003-2004)
The star dated the Young and the Restless when she was just 18-years-old.
The on-and-off duo both starred in the popular 2000s sitcom 8 Simple Rules… for Dating My Teenage Daughter.
Young love: The star dated The Young and the Restless’ Thad Luckinbill when she was just 18-years-old
Jaron Lowenstein (2005-2006)
By 2005 at the age of 19 and 20, she was hot and heavy with singer, Jaron Lowenstein, 44, before the two broke up.
During their one-year relationship, they frequented many red carpets together.
One year later, she ended up landing her breakout role as on The Big Bang Theory, which catapulted her to stardom.
Lovers: By 2005, from the ages of 19 to 20, she was seeing singer Jaron Lowenstein, 44
Al Santos (2007)
She was ‘rumored to be dating,’ the former model, according to Us Weekly.
They met while filming the thriller Killer Movie, which was released in 2008.
She and Al Santos were ‘rumored to be dating,’ the former model, according to Us Weekly; seen in 2006
Johnny Galecki -2007 to 2009
The Emmy nominee quietly dated her Big Bang Theory costar, 46, from 2007 to 2009.
Their characters, Penny and Leonard, were love interests throughout their hit CBS comedy, and even wed in season 10.
When speaking about their relationship on CBS Watch in 2010, she called their relationship ‘wonderful’ but explained they ‘never spoke a word about it and never went anywhere together.’
‘We were so protective of ourselves and the show and didn’t want anything to ruin that,’ she said one year after their split.
Despite the breakup, they’ve stayed close over the years, with Cuoco describing him as one of her ‘best friends’ during an appearance on Watch What Happens Live with Andy Cohen in 2015.
Still friends: The Golden Globe nominee, 35, quietly dated her Big Bang Theory costar Johnny Galecki, 46, from 2007 to 2009; seen in 2016
Josh Resnik -2010 to 2011
One year after splitting from Galecki, Cuoco fell in love with Resnik, an addiction specialist, who proposed to her in October 2011.
He popped the question ‘during a quiet date night at home,’ her rep told People, at the time.
Five months later, however, the pair ended their engagement.
Moved on: One year after splitting from Galecki, Cuoco fell in love with Resnik, an addiction specialist, who proposed to her in October 2011
Christopher French (2011-2012)
She and musician Christopher French, who is now married to Ashley Tisdale, dated from 2011 to 2012.
During their time together, they recorded a duet of Somewhere Over the Rainbow to benefit the Human Society.
In March, he and his wife welcomed their first baby together, daughter Jupiter Iris.
Musical: She and musican Christopher French, who is now married to Ashley Tisdale, dated from 2011 to 2012; seen in 2011
Bret Bollinger (2012 — 2013)
In March 2012, Cuoco dated the lead singer and bassist for the rock band, Pepper.
They were first seen together packing on the PDA at a Lakers game in Los Angeles.
After nearly a year together, they parted ways in January 2013.
Almost a year: In March 2012, Cuoco dated the lead singer and bassist for the rock band, Pepper, but parted aways less than a year later
Ryan Sweeting 2013–2016
Cuoco and the former professional tennis player, 34, got engaged in September 2013 after three months of dating.
The former lovebirds wed in December of that year, but wound up divorcing just 21 months later.
While looking back at their whirlwind romance, she scoffed she and Sweeting ‘got married in, like, six seconds’ to Variety.
During their marriage, she told Cosmopolitan in 2018 that Sweeting ‘completely changed’ and ‘honestly’ had her thinking she would nevr ‘get married again.’
‘My ex ruined that word for me,’ she said. ‘The person I ended up with was not the person I originally met. And that wasn’t my fault — that was his.’
Upon finalizing their divorce, Cuoco paid him $165,000 and covered his attorney fees, according to People.
Whirlwind romance: Cuoco and the former professional tennis player, 34, got engaged in September 2013 after three months of dating
Henry Cavill – 2016
After divorcing Sweeting, she and Henry Cavill were rumored to be dating, after they were seen holding hands and looking cozy.
But just ‘ten days’ after news of them together broke, Us Weekly reported they called it quits.
‘Things fizzled as quickly as they heated up,’ an insider told the outlet. ‘They are still friends.’
Still friends: In 2016, she and Henry Cavill had a quick romance before she began her whirlwind romance with Karl Cook
Karl Cook – 2016 to 2021
Cuoco and Cook, 30, met at a horse show in California in March 2016, months after her messy split from Sweeting in September 2015.
A year and a half later, he got down on one knee and proposed on her birthday in November 2017.
In June, while ringing in their three-year wedding anniversary, they gave no indication of relationship trouble as they raved about their love.
Cook even penned a sweet tribute to his wife, in which he said he couldn’t wait for a ‘million more years’ together.
The couple announced their marriage was over in a joint statement on September 3, declaring that their lives were moving in ‘opposite directions’.
What happened? In June, while ringing in their three-year wedding anniversary, they gave no indication of relationship trouble as they raved about their love; pictured in 2019