Atletico Madrid boast a 2-0 advantage from the first leg of their Champions League round of 16 tie.
Cristiano Ronaldo and co are desperate to turn it around to reach the quarter-finals.
Ronaldo has lifted the Champions League for the last three seasons with Real Madrid.
However, the Portugal international is in serious doubt of winning the prestigious trophy this year.
Despite being 2-0 down, Juventus boss Massimiliano Allegri is confident his side can turn the scoreline around.
“If we were to call this the biggest match of the season, we’d be in real trouble,” he said.
“If we do go through, it’s not as if we’ve won the Champions League, as there are other games.
“We need calm and to take it one game at a time.
“If we manage to overturn the first leg result, it will be extraordinary.
“After that we either think about the quarter-finals or ending the season on the right note.”
Juventus and Atletico are hoping to join Ajax, Manchester United, Tottenham and Porto in the quarter-finals.
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