Roy Hodgson’s side have been in shocking form and need to arrest their slide to prevent a forgettable end to the campaign.
United have rather more at stake, with a Champions League spot still just out of their grasp after two points were dropped late on Monday night.
Ole Gunnar Solskjaer’s side know that three wins from their last three games will guarantee top spot, so there’s no margin for error.
Here’s everything you need to know ahead of the game.
When is it and what time is kick-off?
The match will begin at 8:15pm on Thursday 16 July at Selhurst Park.
How can I watch it online and on TV?
The match will be broadcast live on BT Sport 1 and BT Sport 1 Extra. Coverage starts at 7:30pm.
What is the team news?
Palace are without the suspended Christian Benteke, as well as injured defensive trio Martin Kelly, Gary Cahill and James Tomkins. Jeffrey Schlupp is also out.
United will probably be without Luke Shaw, who went off injured on Monday night, while his replacement Brandon Williams then suffered a head injury. Phil Jones is also out and Mason Greenwood is a doubt after a bad tackle against Southampton.
Palace: Guaita; Ward, Dann, Sakho, Van Aanholt; Milivojevic; Townsend, McArthur, Kouyate, Zaha; Ayew.
United: De Gea; Wan-Bissaka, Lindelof, Maguire, Dalot; Matic, Pogba; James, Fernandes, Rashford; Martial.
What are the odds?
Palace – 21/2
Draw – 9/2
United – 4/1