Aronofsky is known for helming films such as The Wrestler (2008), Mother! (2017) and Black Swan (2010), which earned him an Academy Award nomination.
Fans are already building up some awards buzz for Brendan, hoping the high profile gig will serve as his Oscar-worthy comeback.
Brendan is best known for films in the 1990s such as George of the Jungle (1997) and The Mummy (1999).
The actor has also been seen in The Affair, Trust, and Doom Patrol in recent years.