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The constituency, the largest by area in England and Wales, includes the Brecon Beacons National Park
Voters in Brecon and Radnorshire go to the polls on Thursday to elect a new member of Parliament.
The seat in mid Wales became vacant as a result of the sitting MP being recalled by a petition.
A total of six candidates are standing in the by-election and polling started at 07:00 BST.
Voting closes at 22:00, with the result expected to be announced in the early hours of Friday morning.
