Vivianne Miedema hit four goals in a 5-2 win at Slavia Prague to put Arsenal on the verge of the Women’s Champions League quarter-finals.
The Netherlands striker had a hat-trick inside 39 minutes and added a fourth after half-time.
Kim Little’s penalty made it 5-0 before Katerina Svitkova and Mia Persson cut Arsenal’s lead with late goals.
Glasgow City won 2-0 at Brøndby while Lyon, the European champions, won 4-0 at Fortuna Hjørring with Ada Hegerberg and Eugénie Le Sommer both scoring twice.
Bayern Munich scored five without reply at BIIK Kazygurt while Wolfsburg hit FC Twente for six.