Arsenal will be without suspended midfielder Lucas Torreira.
Alexandre Lacazette is available having missed the Europa League defeat in Rennes through suspension, with long-term injury absentees Danny Welbeck (ankle), Rob Holding and Hector Bellerin (both knee) still missing.
Anthony Martial will return for Manchester United with Nemanja Matic and Ander Herrera also on the brink of returning.
Ole Gunnar Solskjaer revealed that Matic (groin) and Herrera (hamstring) could return, but Alexis Sanchez, Jesse Lingard, Juan Mata, Phil Jones, Antonio Valencia and Matteo Darmian remain unavailable.
Arsenal: Leno, Maitland-Niles, Sokratis, Kscielny, Monreal , Kolasinac, Xhaka, Ramsey, Ozil Aubameyang, Lacazette
Man United: De Gea, Young, Lindelof, Smalling, Shaw, Matic, Fred, Pogba, Dalot, Rashford, Lukaku
Arsenal hold a 1-0 lead over Manchester United at the break at the Emirates Stadium courtesy of Granit Xhaka’s strike. There was little between the two teams in the first half, but David de Gea made a rare mistake for the Red Devils. He allowed Xhaka’s strike from distance to find the back of the net albeit the Swiss struck his effort with a slight bit of swerve. United have come close through Romelu Lukaku, but his close-range effort hit the bar, while Fred struck the foot of the post. It has been an open contest and there could be more goals in this one in the second period.
45+4 minsminute by minute
HALF-TIME: ARSENAL 1-0 MANCHESTER UNITED
45+3 minsminute by minute
Rashford loses possession once again, but Kolasinac fails to punish the forward, sending his attempted lofted pass for Aubameyang out for a throw-in.
45+2 minsminute by minute
Shaw tries to find Rashford in the final third, but the forward takes a loose touch and allows the ball to travel out for a goal-kick.
45 minsminute by minute
There will be two minutes of added time.
45 minsminute by minute
The referee stops an Arsenal counter so Xhaka can receive treatment after taking a blow from Rashford during his block. However, the Swiss appears to be ok to continue.
44 minsminute by minute
Pogba opens up the Arsenal defence with a precise offload into the box for Lukaku. The Belgian takes the ball out of the air before sending Dalot down the flank. He cuts the ball back for Rashford, but Xhaka on the slide makes a vital challenge to stop the strike.
Overall Possession Ratio
42 minsminute by minute
Ramsey battles down the flank to dispossess Young and he runs upfield before trying to release Ozil. However, the German is caught offside. Ozil is having one of those off days for Arsenal thus far.
41 minsminute by minute
Shaw sends Rashford down the left flank and he tries to cut the ball back for Lukaku. Monreal reads the danger and is able to make a firm clearance ahead of the Belgian.
39 minsminute by minute
The visitors take the free-kick short and Shaw clips a cross to the back post for Smalling to challenge. He climbs on the back of Kolasinac, but sends his tame header wide of the post.
38 minsminute by minute
Sokratis wipes out Pogba in the middle of the park and goes into the book. The defender has to be careful again.
36 minsminute by minute
SAVE! Rashford releases Lukaku through the middle and he fends of Monreal. The Belgian tries to round Leno, but the Arsenal keeper does well to make the stop before Lukaku fails to find Fred with his offload. United keep the pressure on, although the Gunners are able to hold firm.
34 minsminute by minute
Lacazette tries to surge through the United defence and offload towards Aubameyang. However, he loses his footing and scoops the ball out for a goal-kick.
33 minsminute by minute
Kolasinac looks to release the run of Ozil in the final third, only for the linesman to raise his flag for offside against the German.
31 minsminute by minute
Shaw sees his cross cleared by Ozil before Dalot goes for the strike from 20 yards, but he places his attempt over the bar.
30 minsminute by minute
Maitland-Niles brings down Shaw on the charge down the left, handing United a free-kick in a good position.
Overall Possession Ratio
29 minsminute by minute
Lacazette works the ball to Kolasinac down the left flank and he fires the ball across the face of goal. However, Aubameyang is on his heels and cannot make contact in the middle.
28 minsminute by minute
Pogba finds Lukaku in space on the edge of the box, but rather than shooting the Belgian clips a cross to the back post. Rashford makes the run, but just cannot make contact as the ball heads out for a goal-kick.
26 minsminute by minute
Pogba lines up an ambitious attempt from distance, but his effort sails into the hands of Leno, who makes the claim with ease.
24 minsminute by minute
BLOCK! Smalling puts his body on the line to divert Lacazette’s strike behind for a corner after the Frenchman had twisted and turned his way past Lindelof.
23 minsminute by minute
Shaw nods the ball down to Rashford in the left inside channel. The forward has space and time, but he volleys the ball out of touch for a goal-kick even with support around him.
22 minsminute by minute
OVER! Ozil runs at the United defence before releasing Maitland-Niles down the right flank. He cuts the ball back for Ramsey in the middle, only for the Welshman to scoop his strike over the bar.
20 minsminute by minute
It has been an open game in the opening 20 minutes of the contest. Both sides have had opportunities, but the one mistake from De Gea has made the difference.
19 minsminute by minute
OFF THE POST! United work the ball with patience on the edge of the box before Pogba picks out Fred. He goes for the strike on his left foot, but it strikes the post and travels behind for a goal-kick.
16 minsminute by minute
Ozil slides an offload into the feet of Lacazette on the edge of the box. The Frenchman takes a touch and should shoot, but he carries on with his run and then sees his eventual strike blocked into the arms of De Gea by Young.
14 minsminute by minute
Six of Xhaka’s seven Premier League goals for Arsenal have come from outside the box, including both against Man Utd.