Midfielders Dele Alli and Jesse Lingard have been left out of England manager Gareth Southgate’s squad for the Euro 2020 qualifiers away to the Czech Republic and Bulgaria.
There is a first call-up for defender Fikayo Tomori, while his Chelsea team-mate, striker Tammy Abraham, has also been picked.
Manchester City right-back Kyle Walker has again been omitted.
England play the Czechs on 11 October and Bulgaria on 14 October.
Everton midfielder Fabian Delph has been recalled, but Liverpool midfielder Alex Oxlade-Chamberlain misses out.
Injured Manchester United right-back Aaron Wan-Bissaka is also not included.
“There have been some difficult decisions to make,” said Southgate. “It’s an exciting squad, with players very much in form.
“There’s still an emphasis on the development of younger players but surrounded by good experience.”
Abraham, 22, had said he had “not made a decision yet” on his international future as he is also eligible to play for Nigeria, having only played for England in two friendlies and not a competitive game.
If he plays against either the Czechs or Bulgaria, he will not be able to switch allegiance, while the same also applies to Tomori who played for Canada at Under-20 level.
“It’s not ethically right to give someone a cap just so they can’t play for someone else,” said Southgate.
“He and Fikayo Tomori are both in on merit and have been part of our junior system right the way through, so we see them as English players and they have a huge desire to play for England at senior level.”
Abraham has netted eight goals in 10 games in all competitions for Chelsea so far this season and is joint second in the Premier League’s top-scorers’ chart.
“It was a fairly easy decision [to pick him] as he’s the leading English goalscorer in the league,” said Southgate.
Abraham played for England in friendly draws with Germany and Brazil in 2017, and was part of the England Under-21 squad at the European Championship this summer.
“We put him into the squad very young, when we were changing the complexion of what we were doing,” added Southgate.
“That was a bit early for him but because of the opportunity given to him by Frank Lampard at Chelsea, we’ve brought him back in.
“This is now a great chance for Tammy.”
England squad:
Goalkeepers: Tom Heaton (Aston Villa), Jordan Pickford (Everton), Nick Pope (Burnley)
Defenders: Trent Alexander-Arnold (Liverpool), Ben Chilwell (Leicester), Joe Gomez (Liverpool), Michael Keane (Everton), Harry Maguire (Manchester United), Tyrone Mings (Aston Villa), Danny Rose (Tottenham), Fikayo Tomori (Chelsea), Kieran Trippier (Atletico Madrid)
Midfielders: Ross Barkley (Chelsea), Fabian Delph (Everton), Jordan Henderson (Liverpool), James Maddison (Leicester), Mason Mount (Chelsea), Declan Rice (West Ham), Harry Winks (Tottenham)
Forwards: Tammy Abraham (Chelsea), Harry Kane (Tottenham), Marcus Rashford (Manchester United), Jadon Sancho (Borussia Dortmund), Raheem Sterling (Manchester City), Callum Wilson (Bournemouth)
